Laboratory Smoking of Marijuana "Blunts"

Battelle Memorial Institute

Status and phase: Completed; Phase 1

Conditions: Cannabis

Treatments: Drug: Marijuana

Study type: Interventional

Funder types: Other

Identifiers

NCT03546790

BMI-104112

Details and patient eligibility

About

This is a double-blind within-subjects clinical laboratory study comparing the product appeal and abuse liability-related subjective effects of different flavored cigar wrappers for marijuana blunts.

Enrollment: 8 patients

Sex: All

Ages: 18 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Currently living in Baltimore City or Baltimore County, MD;
• Able to read, understand, and sign informed consent;
• 18-55 years old;
• Currently smokes marijuana blunts;
• Designation of Medically Healthy for Research by the Study Physician; and
• Willing to abstain from illicit drug use other than marijuana for the duration of the study.

Exclusion criteria

• BAC > 0.020% as measured by alcohol breathalyzer;
• Meets DSM-5 criteria for severe current or lifetime Cannabis Use Disorder;
• Meets DSM-5 criteria for any current Axis I disorder, other than current mild or moderate Cannabis Use Disorder;
• Self-reported current desire to stop marijuana use;
• Self-reported current asthma, chronic obstructive pulmonary disease, hypertension, cardiovascular disease or any other medical illness that precludes participation;
• Has difficulties with blood draws or poor venous access;
• History of blood donation in the past 30 days or receiving blood products within the past 2 months prior to any experimental visit;
• Among females, current pregnancy or lactation or attempting to get pregnant, or at risk of becoming pregnant;
• Acute illness which will require participant to be rescheduled

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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8 participants in 3 patient groups

Flavor 1

Experimental group

Description:

Grape flavored tobacco cigar wrapper

Treatment:

Drug: Marijuana

Flavor 2

Experimental group

Description:

Chocolate flavored tobacco cigar wrapper

Treatment:

Drug: Marijuana

Flavor 3

Experimental group

Description:

Tobacco flavored tobacco cigar wrapper

Treatment:

Drug: Marijuana