Laboratory Study of Early Tumor Markers in the Peripheral Blood of Glioblastoma Multiforme Patients

University of Florida

Status: Completed

Conditions: Healthy Volunteers; Glioblastoma Multiforme

Treatments: Other: Normal Controls; Other: GBM Patients

Study type: Observational

Funder types: Other

Identifiers

NCT01135875

CTC-01

Details and patient eligibility

About

The purpose of this study is to determine if tumor cells can be detected in the blood of patients diagnosed with a brain tumor.

Full description

Despite aggressive therapies, Glioblastoma Multiforme (GBM) is rapidly fatal. GBMs are increasingly recognized for occasionally metastasizing through the peripheral blood to distant locations. This research study involves the detection and novel characterization of human GBM (hGBM) circulating tumor cells (CTCs) within the peripheral blood of brain tumor patients by identifying their unique cell surface antigen profile, determining an optimal isolation protocol, and quantitatively and qualitatively reporting the yield and characteristics.

Enrollment: 130 patients

Sex: All

Ages: 18 to 89 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 18 to 89 years of age
• Weight of at least 110 pounds
• Able to provide informed consent for self

Exclusion criteria

• Patients with active malignant tumors other than GBM

Trial design

130 participants in 2 patient groups

GBM Patients

Description:

GBM Patients with a histologically confirmed or suspected diagnosis of glioblastoma multiforme.

Treatment:

Other: GBM Patients

Normal Controls

Description:

Normal Controls will be adult volunteers who identify themselves as not having been diagnosed with a glioblastoma multiforme.

Treatment:

Other: Normal Controls