Lack of Acute Tolerance Development to Effects of Nitrous Oxide - 4

The University of Chicago

Status and phase: Completed; Phase 2

Conditions: Opioid-Related Disorders; Substance-Related Disorders

Treatments: Drug: 0% N2O; Drug: 20% N2O; Drug: 10% N2O; Drug: 40% N2O; Drug: 30% N2O

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT00000252

NIDA-08391-4

R01DA008391 (U.S. NIH Grant/Contract)

R01-08391-4

Details and patient eligibility

About

The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To examine the lack of acute tolerance development to the subjective, cognitive, and psychomotor effects of nitrous oxide in healthy volunteers.

Enrollment: 11 patients

Sex: All

Ages: 21 to 29 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Please contact site for information.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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11 participants in 5 patient groups

0% N2O

Sham Comparator group

Description:

Subjects will inhale 0% N2O

Treatment:

Drug: 0% N2O

10% N2O

Active Comparator group

Description:

Subjects will inhale 10% N2O

Treatment:

Drug: 10% N2O

20% N2O

Active Comparator group

Description:

Subjects will inhale 20% N2O

Treatment:

Drug: 20% N2O

30% N2O

Active Comparator group

Description:

Subjects will inhale 30% N2O

Treatment:

Drug: 30% N2O

40% N2O

Active Comparator group

Description:

Subjects will inhale 40% N2O

Treatment:

Drug: 40% N2O