Lactate Kinetics Analysis Related to Low-Intensity Resistance Exercise

Dr Cipto Mangunkusumo General Hospital

Status: Completed

Conditions: Lactate; Fatigue

Treatments: Device: Virtual Reality Exercise (VRE) using VRAGMENT software

Study type: Interventional

Funder types: Other

Identifiers

NCT07149272

KET-261/UN2.F1/ETIK/PPM.00.02/

Details and patient eligibility

About

The goal of this study aims to analyze lactate kinetics as an exercise response after conventional multimodal exercise and virtual reality exercise (VRE) in hospitalized geriatric. The main question it aims to answer are:

1. are there any difference in post exercise lactate at day 1 and 7 between the two groups?
2. does the lactate concentration reduces after low intensity resistance exercise in subject with high resting lactate?

Participants were randomized into control and VRE group. Peripheral blood lactate was taken immediately before and after low-intensity resistance exercise at baseline and one week after

Full description

Sixty geriatric patients were recruited during their hospitalization at RSUPN Dr. Cipto Mangunkusumo (RSCM). Subjects were randomized into control and intervention group. Both groups get conventional multimodal exercise, the intervention group gets additional VRE as adjuvant therapy. Exercise prescription was given after the subjects going through functional assessment conducted by physiatrists. The prescription described the frequency, intensity, interval, and type of exercise that is adjusted to subject's clinical condition. Each subject could have more than one type of exercise, but the most common combination consists of breathing, resistance, and aerobic exercises. VRAGMENT software was administered as VRE to the intervention group. In VRAGMENT, subjects should make phone call, groceries and making payment. Those activities in virtual environment initiated real movement of neck, trunk, arms, and legs. Capillary blood lactate sample was examined using StatStrip® from Nova Biomedical. Measurement range of StatStrip® is 0,3 - 20,0 mmol/L. Lactate examination conducts at baseline and one week after the exercise program. Blood samples were collected immediately pre and post-standardized low-intensity resistance training. The data collected were analyzed using SPSS statistics (version 24.0).

Enrollment: 60 patients

Sex: All

Ages: 60 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient age 60-90 years old in acute geriatric ward
• mobilization level 3 and 4
• able to communicate and follow instructions

Exclusion criteria

• VR Sickness
• severe psychosocial problems
• severe caregiver burden

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

60 participants in 2 patient groups

Control Group

No Intervention group

Description:

Conventional multimodal exercise (standard care)

VRE Intervention Group

Experimental group

Description:

Conventional exercise + Virtual Reality Exercise (VRAGMENT software on Oculus Quest 2)

Treatment:

Device: Virtual Reality Exercise (VRE) using VRAGMENT software