Lactate Levels Correlates With Ki-67 in Brain Tumor Surgery

Ricard Valero

Status: Completed

Conditions: Brain Tumor; Anesthesia

Treatments: Other: Data correlation

Study type: Observational

Funder types: Other

Identifiers

NCT03531307

Lac001Ki67

Details and patient eligibility

About

In neurosurgery, brain tumor patients show increased levels of lactate at the beginning of surgery. This has been related to malignancy. Ki-67 is a cell proliferation index used as a marker of tumor mitotic activity.

This research aims to describe the correlation between lactate levels and the Ki-67 index in patients with brain tumor.

Full description

Lactate levels are used in the evaluation of perfusion status in critical care. Increases not related to a hypoperfusion state are observed in the patient with brain tumors. These increases have been related to type and tumor grade. This observation does not fully explain the variation within the same tumor grade.

Ki-67 label index is a marker of mitotic activity that can be used as proliferation index. It has been associated with histologic grade and survival rate. Provides a quantitative measure of the tumor proliferation status.

The investigators will perform a retrospective analysis of the clinical charts of patients after brain tumor resection. The study will address the relationship between baseline lactate levels and the proliferation index found in tissues biopsies.

Enrollment: 100 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Neurosurgical craniectomy cases
• June 2017 - February 2018
• Valid lactate information after anesthesia induction
• Ki-67 label index informed in biopsies
• Tumor type information confirmed in biopsies

Exclusion criteria

• Incomplete lactate or Ki-67 index information

Trial design

100 participants in 1 patient group

Lactate and Ki 67 levels

Description:

Neurosurgical patients between June 2017 and February 2018 for tumoral and non-tumoral craniectomy with lactate levels at the beginning of surgery and Ki-67 index in biopsies.

Treatment:

Other: Data correlation