Lactobacillus Plantarum IS 10560 Supplementation in Women With Functional Constipation

University of Indonesia (UI)

Status and phase

Completed

Phase 3

Phase 2

Conditions

Constipation - Functional

Treatments

Drug: Lactobacillus plantarum

Drug: Placebo

Study type

Interventional

Funder types

Other

Other U.S. Federal agency

Identifiers

NCT03885973

18-01-0060

Details and patient eligibility

About

In this study, the investigators measured the SCFA (Butyrate, Acetate and Propionate) as a Biomarker improvement symptom and quality of life women with functional constipation after supplementation of commensal bacterial fermented milk Lactobacillus plantarum (isolated from indigenous probiotics from Dadih, West Sumatra) for 21 days

Enrollment

76 patients

Sex

Female

Ages

18 to 60 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Being declared healthy based on initial examination and the Structured Interview Questionnaire (SIQ)
Having the symptoms and signs of functional constipation refer to ROME IV
Able to communicate well
Able to consume 1 bottle of fermented milk each day for three weeks
Not using antibiotic no later than one week before supplementation

Exclusion criteria

Diagnosed with functional bowel disorder
Using anesthesia at least 4 weeks before treatment
Having a serious pathological disorder (carcinoma)
During healing phase of acute gastrointestinal disorders at least 4 weeks before treatment
Having severe heart disease
Taking chronic medications such as antidepressants or analgesics