Lactobacillus Reuteri Strains for Gingivitis Reduction

Universidad Autonoma de San Luis Potosí

Status: Completed

Conditions: Gingival Inflammation

Treatments: Dietary Supplement: L. reuteri (DSM 17938 and ATCC PTA 5289) in form of oral tablets

Study type: Interventional

Funder types: Other

Identifiers

NCT06234839

LLeuteri220124

Details and patient eligibility

About

The aim of the present study was to investigate the potential beneficial effects in volunteer young adults of orally administered L. reuteri (DSM 17938 and ATCC PTA 5289) on gingival inflammation. The null hypothesis was that no difference would be manifested by probiotic therapy regarding the conventional mechanical treatment (without probiotic administration).

Full description

Aim. To investigate the potential beneficial effects in volunteer young adults of orally daily administered L. reuteri (DSM 17938 and ATCC PTA 5289) on gingival inflammation. The null hypothesis was that no difference would be manifested by probiotic therapy regarding the conventional mechanical treatment (without probiotic administration).

Methods. A randomized controlled parallel clinical trial was conducted in sixty young adults (18-35 yrs old) with chronic marginal gingivitis for one month. Initially, both study groups underwent conventional mechanical periodontal therapy/oral anti-plaque hygiene. However, the experimental group additionally received the administration of two daily tablets, containing both L. reuteri strains, for 30 days, while the control group did not. Different clinical outcome variables (plaque (PI) and gingival (GI) indices, bleeding on probing (BOP), and crevicular fluid volume (CFV)) were recorded and compared between the study groups, both at baseline and at the end of the interventions, 30 days later. Statistical descriptive and inferential tests were performed (data distribution normality, Student's t, and Wilcoxon-Mann-Whitney tests).

Enrollment: 60 patients

Sex: All

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Non-smokers (at least for the last 6 months).
• Initial mean gingival index (GI) between 1.5 - 2.
• With a minimum of 20 teeth present in the oral cavity.

Exclusion criteria

• Periodontal pockets > 4 mm.
• Recent intake of antibiotics or anti-inflammatory drugs and/or reception of dental prophylaxis.
• Daily consumption of analgesics, probiotics, or oral antimicrobial rinses/gels.
• Overweight (MCI >25).
• Alcohol or recreative drug frequent consumers.
• Pregnancy or breast-feeding.
• Allergy or hypersensitivity to study products
• Fixed orthodontic appliances.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

60 participants in 2 patient groups

Probiotic group

Experimental group

Description:

The experimental group received conventional mechanical periodontal therapy and oral anti-plaque hygiene training, plus the administration of two daily tablets, containing both L. reuteri strains, for 30 days.

Treatment:

Dietary Supplement: L. reuteri (DSM 17938 and ATCC PTA 5289) in form of oral tablets

No probiotic group

No Intervention group

Description:

The control group also received conventional mechanical periodontal therapy and oral anti-plaque hygiene training; however, this group did not receive the administration of the probiotic tablets.