Lactoferrin Efficacy Versus Ferrous Sulfate in Treatment of Patients With Iron Deficiency Anemia

Assiut University

Status and phase: Completed; Phase 4

Conditions: Iron Deficiency Anemia Treatment

Treatments: Drug: Lactoferrin Bovine; Drug: Ferrous Sulfate

Study type: Interventional

Funder types: Other

Identifiers

NCT04267653

17100915

Details and patient eligibility

About

Lactoferrin (Lf) is a mammalian cationic iron binding glycoprotein belonging to the transferrin family which was discovered 70 years ago, and isolated simultaneously from human and bovine milks in 1960. It is widely distributed in all biological fluids and is also expressed by immune cells, which release it under stimulation by pathogens

Enrollment: 96 patients

Sex: All

Ages: 2 to 15 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:all patients with iron deficiency anemia from 2 to 15 years old

Exclusion Criteria:

• Anemia rather than iron deficiency anemia.
• Family history of blood disease.
• Patients with thalassemia trait.
• Patients with chronic illness.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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96 participants in 3 patient groups

lactoferrin

Active Comparator group

Description:

Oral bovine lactoferrin (bfl) 100 mg once daily on empty stomach

Treatment:

Drug: Lactoferrin Bovine

ferrous sulfate

Active Comparator group

Description:

Oral ferrous sulfate 3-6 mg/kg of elemental iron/day in divided doses

Treatment:

Drug: Ferrous Sulfate

combined

Active Comparator group

Description:

combined therapy (both lactoferrin and ferrous sulfate)

Treatment:

Drug: Ferrous Sulfate

Drug: Lactoferrin Bovine