LANDSCAPE: Demographics and Treatment Patterns of Patients With Immune-Mediated Inflammatory Skin Diseases in Italian Clinical Practice

Fondazione ISIDE

Status: Not yet enrolling

Conditions: Atopic Dermatitis; Psoriasis; Vitiligo; Hidradenitis Suppurativa; Alopecia Areata

Treatments: Drug: Conventional Systemic Therapies; Drug: Biologic Therapies

Study type: Observational

Funder types: Other

Identifiers

NCT07336641

ISIDE-LANDSCAPE-2025-001

Details and patient eligibility

About

This multicenter retrospective observational registry study will collect existing clinical data from Italian centers to describe epidemiology, treatment patterns, clinical evolution, safety, and comorbidities in patients aged 12 years and older with psoriasis, atopic dermatitis, vitiligo, alopecia areata, or hidradenitis suppurativa.

Full description

LANDSCAPE is a non-interventional, multicenter, retrospective disease registry based on routinely collected clinical data (electronic health records and available medical documentation) from participating Italian centers. Data will cover the period January 2016 to December 2025. The registry will support real-world evaluation of treatment patterns, effectiveness and safety outcomes, disease severity scores, persistence/switching, and associated comorbidities across psoriasis, atopic dermatitis, vitiligo, alopecia areata, and hidradenitis suppurativa. Data will be pseudonymized prior to entry into the EDC system. Patients who exercise the opt-out right will not be included.

Enrollment: 20,000 estimated patients

Sex: All

Ages: 12+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Documented diagnosis of psoriasis, atopic dermatitis, vitiligo, alopecia areata, or hidradenitis suppurativa.
2. Age 12 years or older at the first recorded visit.
3. Eligible for or treated with systemic therapies.
4. At least one documented visit during January 2016 to December 2025.
5. No opt-out exercised.

Exclusion criteria

1. Opt-out exercised.
2. Medical records with insufficient data.

Trial design

20,000 participants in 5 patient groups

Psoriasis Cohort

Description:

Adult patients (≥18 years) diagnosed with moderate-to-severe psoriasis according to clinical criteria, treated with systemic conventional and/or biologic therapies at participating Italian dermatology centers. No intervention is administered; data are collected retrospectively from medical records.

Treatment:

Drug: Biologic Therapies

Drug: Conventional Systemic Therapies

Atopic Dermatitis Cohort

Description:

Adult patients (≥18 years) diagnosed with moderate-to-severe atopic dermatitis, treated with systemic conventional and/or biologic therapies at participating Italian dermatology centers. No intervention is administered; data are collected retrospectively from medical records.

Treatment:

Drug: Biologic Therapies

Drug: Conventional Systemic Therapies

Alopecia Areata Cohort

Description:

Adult patients (≥18 years) diagnosed with alopecia areata, treated with systemic therapies at participating Italian dermatology centers. No intervention is administered; data are collected retrospectively from medical records.

Treatment:

Drug: Biologic Therapies

Drug: Conventional Systemic Therapies

Vitiligo Cohort

Description:

Adult patients (≥18 years) diagnosed with vitiligo, treated at participating Italian dermatology centers. No intervention is administered; data are collected retrospectively from medical records.

Treatment:

Drug: Biologic Therapies

Drug: Conventional Systemic Therapies

Hidradenitis Suppurativa Cohort

Description:

Adult patients (≥18 years) diagnosed with hidradenitis suppurativa, treated with systemic conventional and/or biologic therapies at participating Italian dermatology centers. No intervention is administered; data are collected retrospectively from medical records

Treatment:

Drug: Biologic Therapies

Drug: Conventional Systemic Therapies