LAnguage-Motor Imagery Circuits to Improve Motor Learning and Language Comprehension (LAMI)

Grenoble Alpes University Hospital Center (CHU)

Status: Enrolling

Conditions: Corticospinal Excitability; Cortical Activation

Treatments: Other: Action reading; Other: Motor localizer; Other: Motor imagery

Study type: Observational

Funder types: Other

Identifiers

NCT06478303

38RC23.0349

2023-A02322-43 (Other Identifier)

Details and patient eligibility

About

Recent evidence suggests that cognitive systems do not operate in isolation but interact within broader networks, thus opening new avenues for fundamental and clinical research. An illustrative example is the interaction between language comprehension and motor representations. For instance, motor training (e.g., sports, origami training) can facilitate action verb recognition, whereas motor deficits (e.g., upper limb immobilization) can hinder the processing of action language. Similarly, action language has been shown to affect motor performance. These effects are attributed to an implicit form of motor imagery, an automatic simulation of motor experience (without actual movement) evoked by action words. Interestingly, literature supports the idea that the motor simulations used for imagining an action are also engaged during the reading of action language, leading to similar neurophysiological and behavioral changes in both processes. However, questions remain about the similarity of the simulations generated by motor imagery and action language. This project, encompassing three experimental sequences, aims to address these questions to achieve significant scientific advancements in both theoretical and applied domains.

Enrollment: 105 estimated patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• persons who have given written consent,
• healthy subjects
• subjects reading and understanding French
• right-handed,
• affiliated with a social security system,
• between 18 and 40 years old,
• had completed the TMS inclusion questionnaire or had undergone a medical examination prior to participation in the MRI study.

Exclusion criteria

• Existence of a severe general medical condition: cardiac, respiratory, hematological, renal, hepatic, cancerous,
• Regular use of anxiolytics, sedatives, antidepressants, neuroleptics,
• Characterized psychiatric pathology,
• Ingestion of alcohol prior to the examination,
• Persons covered by articles L1121-5 to L1121-8 of the CSP,
• Presence of contraindications to MRI or TMS.

Trial design

105 participants in 5 patient groups

TMS Experimental group

Treatment:

Other: Motor imagery

Other: Action reading

fMRI Experimental group

Treatment:

Other: Motor imagery

Other: Motor localizer

Other: Action reading

Experimental ccPAS group

Treatment:

Other: Motor imagery

Other: Action reading

Sham ccPAS group

Treatment:

Other: Motor imagery

Other: Action reading

control group

Treatment:

Other: Motor imagery

Other: Action reading