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Laparoscopic Sacrocolpexy Versus Lateral Suspension (SUSPENSION)

P

Public Assistance-Hospitals of Marseille (AP-HM)

Status

Completed

Conditions

Pelvic Organ Prolapse

Treatments

Procedure: Surgical treatment of genital prolapse

Study type

Interventional

Funder types

Other

Identifiers

NCT03582852
2017-43
2017-A02650-53 (Registry Identifier)

Details and patient eligibility

About

Surgical treatment of genital prolapse can be performed by laparoscopic surgery or by vaginal surgery, with or without using meshes. Laparoscopic sacrocolpopexy, which consist in fixing a mesh between vaginal anterior wall and the promontory is the gold standard procedure to treat anterior prolapse or of the vaginal vault. Most of studies shows a success rate of 80% of this procedure.

However, access to the promontory could be difficult in patients because of adherences or anatomical reasons. This step of the procedure also exposes to risk of ureteral or vascular injuries. Recent issues have also found spondylodiscitis cases.

The technique of laparoscopic lateral suspension with mesh was developed by Dubuisson in 1998 allows not to have to approach the promontory and avoids both the risk of vascular injury and ureteral damage of laparoscopic sacrocolpopexy. Instead of attach the mesh to the promontory, the procedure consists in spreading out bilaterally, a subperitoneal T-shaped mesh in the anterior abdominal wall. The aim of this study is to compare the clinical and functional efficiency of the lateral suspension versus laparoscopic sacrocolpopexy.

It is a prospective, randomized, monocentric study compared two groups The study hypothesis is that the lateral suspension would provide correction than the laparoscopic sacrocolpopexy.

The primary outcome is the comparison of anatomic correction rates at 1 year Success is defined as 1 year Ba et C points < -1 centimeter in POP-Q international score.

Secondary endpoints are improve of quality of life evaluated with the validated P-QOL questionnaire, and complications rates, including post-operative posterior prolapse.

Number of subjects required is 72 patients, 36 in each group having a laparoscopic sacrocolpopexy or lateral suspension.

Outcomes will be evaluated at 1 month and 1 year post-operative consultation

Enrollment

7 patients

Sex

Female

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Patients at least 18 years old.
  • Patients who agreed to participate in the study and signed informed consent.
  • Patient affiliated to a social protection system.
  • Surgical indication by laparoscopy of prolapse cure symptomatic of the anterior stage and / or isolated medium.

Exclusion criteria

  • Minor patient.
  • Patient refusing to sign the consent or unable to receive the necessary information to give informed consent.
  • Patient not affiliated to a social protection system.
  • Presence of one or more contraindication (s) to laparoscopy
  • Presence of posterior prolapse requiring surgical treatment
  • Need for an associated surgical procedure.
  • Major people under legal protection

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Single Blind

7 participants in 2 patient groups

promontory
Active Comparator group
Description:
Laparoscopic sacrocolpopexy, which consist in fixing a mesh between vaginal anterior wall
Treatment:
Procedure: Surgical treatment of genital prolapse
laparoscopic lateral suspension
Active Comparator group
Description:
The procedure consists in spreading out bilaterally, a subperitoneal T-shaped mesh in the anterior abdominal wall
Treatment:
Procedure: Surgical treatment of genital prolapse

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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