Laparoscopic Sleeve Gastrectomy-Induced Decline in Plasma Asprosin and Its Association With Metabolic Recovery

Northern Jiangsu People's Hospital

Status: Completed

Conditions: Obesity, Morbid

Treatments: Procedure: surgery

Study type: Observational

Funder types: Other

Identifiers

NCT07008274

NorthernJiangsu123

Details and patient eligibility

About

the present study aimed to systematically assess the changes in plasma asprosin levels at 3, 6, and 12 months after LSG, to explore the relationships between asprosin dynamics and key metabolic parameters, including body mass index (BMI), fasting glucose, insulin resistance assessed by the homeostasis model (HOMA-IR), and lipid profiles, and to compare asprosin concentrations between bariatric patients and healthy normal-weight controls.

Enrollment: 85 patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. age between 18 and 65 years;
2. body mass index (BMI) ≥37.5 kg/m², or BMI ≥32.5 kg/m² with at least one obesity-related comorbidity;
3. availability of complete clinical data and stored plasma samples at preoperative baseline and at 3, 6, and 12 months postoperatively.

Exclusion criteria

1. history of prior bariatric or gastrointestinal surgery;
2. active malignancy, chronic inflammatory or infectious disease, or severe hepatic or renal dysfunction;
3. pregnancy during the study period;
4. incomplete clinical or biochemical data.

Trial design

85 participants in 1 patient group

surgery

Description:

surgery

Treatment:

Procedure: surgery