Large Language Models Assist in Tumor MDT

Sun Yat-sen University

Status: Enrolling

Conditions: Breast Cancer; Lung Cancer; Liver Cancer; Stomach Cancer; Colorectal Cancer

Treatments: Other: LLM assists in MDT report writing

Study type: Interventional

Funder types: Other

Identifiers

NCT07504367

SYSKY-2026-071-02

Details and patient eligibility

About

Multidisciplinary teams (MDTs) represent the gold standard for personalized tumor treatment, but they are limited by medical resources and accessibility Limitation. Although large language models (LLMs) have shown promise in medical reasoning, their multidisciplinary practicality in pan-cancer MDTs has not been fully explored. In the early stage of this project, LLMs with high clinical application efficacy were identified through benchmark tests, and an open-label randomized controlled study (RCT) was conducted based on these LLMs. The research aims to explore whether AI-assisted assistance can enhance the accuracy and writing efficiency of MDT diagnosis and treatment reports. This study intends to prospectively collect the diagnosis and treatment information of 20 patients and MDT diagnosis and treatment information. It is planned to recruit 40 junior doctors. Doctors in the intervention group will use LLM to assist in the writing of MDT reports, while doctors in the control group will use traditional information retrieval methods for the writing of MDT reports. Three clinical experts ultimately used a standardized Likert scale to conduct comprehensive and multidisciplinary scoring of the MDT reports of the intervention group and the control group. This study quantitatively compared the diagnosis and treatment quality and efficiency of the MDT AI-assisted model and the traditional model to verify the application potential of large language models in assisting tumor diagnosis and treatment.

Enrollment: 60 estimated patients

Sex: All

Ages: 25 to 33 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• A junior doctor with a practicing physician qualification certificate.
• Oncologists, surgeons, radiation oncologists, radiologists and pathologists with 3 to 5 years of clinical experience.
• Age: 25 to 33 years old, gender not limited.
• During the research period, one can participate for no less than 10 hours.
• Agree to participate in this research and sign the informed consent form.

Exclusion criteria

• Have participated in the previous diagnosis and treatment of any one of the 20 cases included in the study.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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60 participants in 2 patient groups

AI-MDT

Experimental group

Description:

This study was a prospective RCT, and the intervention content was an auxiliary tool for writing MDT reports. The intervention group used LLM to assist in the writing of MDT reports. The prescribed MDT medical records (excluding diagnosis and treatment opinions) were input into the LLM, and the output content could be used as a reference for the MDT report. Finally, the MDT diagnosis and treatment opinions were written under the personal judgment of the doctors.

Treatment:

Other: LLM assists in MDT report writing

Trad-MDT

No Intervention group

Description:

The control group used traditional information retrieval methods (such as Google, literature, and textbooks) to write MDT diagnosis and treatment opinions.