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Large Language Models to Aid Gynecological Oncology Treatment (EASING)

P

Philipps University Marburg

Status

Enrolling

Conditions

Breast Cancer

Treatments

Other: Local language model
Other: Guideline pdf

Study type

Interventional

Funder types

Other

Identifiers

NCT06865534
25-29 ANZ (Other Identifier)

Details and patient eligibility

About

This trial aims to assess the impact of providing medical students with access to large language models, in comparison to treatment guideline pdfs, on treatment concordance with a conventional multidisciplinary tumor board

Full description

Advanced artificial intelligence (AI) technologies, particularly large language models such as OpenAI's ChatGPT, hold significant potential for enhancing medical decision-making. While ChatGPT was not specifically designed for medical applications, it has shown utility in various healthcare scenarios, including answering patient inquiries, drafting medical documentation, and aiding clinical consultations. Despite these advancements, its role in supporting treatment decision-making-particularly in complex oncological cases-remains underexplored.

Treatment decision-making in gynecological oncology is a multifaceted process that integrates evidence-based guidelines, tumor biology, patient-specific factors, and clinical expertise. AI tools like ChatGPT could potentially assist in synthesizing relevant guideline-based recommendations, improving decision accuracy, and facilitating more efficient clinical workflows. However, ChatGPT is not specifically tailored for oncological treatment decisions and lacks comprehensive validation in this domain. Additionally, it may generate misinformation or plausible-sounding but inaccurate recommendations, which could impact clinical judgment. Therefore, understanding how medical professionals, including students and early-career physicians, interact with such AI tools is essential before broader integration into clinical practice. Locally deployable models, such as Llama, enable secure, on-premise usage while retrieval-augmented generation ensures guideline-compliant recommendations.

This study will investigate the impact of language models on treatment decision support for medical students managing gynecological oncology cases. This is a crossover study, where participants will be randomized into two groups. All participants begin with access to ChatGPT for two vignettes. They then proceed with two cases using either a locally deployed language model, followed by two cases relying on guideline PDFs, or vice versa.

Each participant will analyze clinical cases, propose treatment plans, and rate their confidence in their decisions and decision support system usability. This study aims to provide insights into the potential benefits and limitations of integrating AI tools like ChatGPT into oncological treatment decision-making.

Enrollment

68 estimated patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

- Medical students having started with clinical subjects

Exclusion criteria

- Not being a medical student

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

Single Blind

68 participants in 2 patient groups

Local language model first
Other group
Description:
Group will be given access to local language model first after using ChatGPT
Treatment:
Other: Local language model
Guideline pdf first
Other group
Description:
Group will be given access to guideline pdf first after using ChatGPT
Treatment:
Other: Guideline pdf

Trial contacts and locations

1

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Central trial contact

Johannes Knitza, MD PhD; Sebastian Griewing, MD PhD

Data sourced from clinicaltrials.gov

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