Large-scale Expansion and Characterization of Mesenchymal Stem Cells for Clinical Application

Chin-Hung Chang

Status: Unknown

Conditions: Knee Injuries

Treatments: Other: 103024-F

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT02375568

201405EMO

Details and patient eligibility

About

According to many recent research, mesenchymal stem cells (MSC) isolated from synovial membrane and infrapatellar fat pad have higher ex vivo proliferation capacity, multipotency and ability to undergo chondrogenesis.

Based on this concept, the investigators plan to get two removed tissues (synovial membrane and infrapatellar fat pad) from patients who have an operation of total knee replacement. The investigators are going to isolate and expand MSC from these two tissues respectively, and then compare the chondrogenesis ability for clinical application. In the other hand, the investigators plan to build techniques and procedures which comply with "Good Tissue Practices (GTP)"

Enrollment: 6 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

Patient who have an total knee replacement surgery

Exclusion criteria

Patient who don't sign the agreement

Trial design

6 participants in 1 patient group

103024-F

Description:

For patients who have an operation of total knee replacement, two removed tissues (synovial membrane and infrapatellar fat pad) will be collected for mesenchymal stem cell isolation.

Treatment:

Other: 103024-F