Laryngeal Injuries After Anesthesia Induction With Sevoflurane and After Anesthesia Induction With Rocuronium

University of Rostock

Status: Completed

Conditions: Laryngeal Injuries

Treatments: Drug: Sevoflurane; Drug: Rocuronium

Study type: Interventional

Funder types: Other

Identifiers

NCT01591031

A 2011 124

Details and patient eligibility

About

Anesthesia induction with sevoflurane is not associated with an increased incidence or severity of laryngeal injuries compared with an anesthesia induction with a muscle relaxant.

Enrollment: 60 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ear-nose-throat surgery
• orotracheal intubation for surgery of the ear

Exclusion criteria

• obesity
• allergy against the study drugs
• patients with a known or suspected difficult airway (Mallampati score 3 or 4 and a mouth opening < 3.5 cm).
• all patients were examined by stroboscopy one day before surgery and were excluded from the study when preexisting pathologies of the vocal cords were found

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

---

60 participants in 2 patient groups

sevoflurane

Active Comparator group

Description:

anesthesia induction with propofol, remifentanil and sevoflurane

Treatment:

Drug: Sevoflurane

rocuronium

Active Comparator group

Description:

anesthesia induction with propofol, remifentanil and rocuronium

Treatment:

Drug: Rocuronium