Laryngeal Injuries After Anesthesia Induction With Three Different Sevoflurane Concentrations (Without Muscle Relaxant) (SEVODosage)

University of Rostock

Status: Completed

Conditions: Other Specified Injuries of Vocal Cord, Sequela

Treatments: Drug: sevoflurane 1,4; Drug: sevoflurane 1,0; Drug: sevoflurane 1,2

Study type: Interventional

Funder types: Other

Identifiers

NCT01896245

A 2013-0039

Details and patient eligibility

About

Anesthesia induction and tracheal intubation can be performed with and without neuromuscular blocking agents (NMBAs). Tracheal intubation can be performed with sevoflurane instead of NMBAs; intubating conditions are similar and the incidence of vocal cord injuries are similar, too.

Full description

We perform tracheal intubation with propofol, remifentanil and sevoflurane; sevoflurane is administered with three dosages. During tracheal intubation intubating conditions are noted. After surgery, all patients are examined by video laryngoscopy; moreover all patients are asked for hoarseness and sore throat.

Enrollment: 90 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ear-nose-throat surgery
• orotracheal intubation for surgery of the ear
• ASA I-III

Exclusion criteria

• obesity
• allergy against the study drugs
• patients with a known or suspected difficult airway
• diseases of the larynx

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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90 participants in 3 patient groups

sevoflurane 1,0

Active Comparator group

Description:

sevoflurane 1,0: sevoflurane is administered with a concentration of 1,0 MAC

Treatment:

Drug: sevoflurane 1,0

sevoflurane 1,2

Active Comparator group

Description:

sevoflurane 1,2: sevoflurane is administered with a concentration of 1,2 MAC

Treatment:

Drug: sevoflurane 1,2

sevoflurane 1,4

Active Comparator group

Description:

sevoflurane 1,4: sevoflurane is administered with a concentration of 1,4 MAC

Treatment:

Drug: sevoflurane 1,4