Laryngeal Injuries After Removal of the Tracheal Tube: A Comparison Between Sevoflurane and Propofol

University of Rostock

Status: Completed

Conditions: Vocal Cord; Injury, Superficial

Treatments: Drug: propofol; Drug: Sevoflurane

Study type: Interventional

Funder types: Other

Identifiers

NCT01616966

A 2010 29

Details and patient eligibility

About

Vocal cord injuries occur not only during tracheal intubation, but also during surgery and during removal of tracheal tube. Volatile anesthetics increase neuromuscular block of muscle relaxants. Thus, the investigators tested the hypothesis, that sevoflurane would cause less vocal cord injuries than a total intravenous anesthesia with propofol.

Full description

Volatile anaesthetics increase neuromuscular block of neuromuscular blocking drugs. We tested the hypothesis, that sevoflurane would cause less vocal cord injuries than an intravenous anaesthesia with propofol. Sixty five patients were randomly assigned to the SEVO group (anaesthesia with sevoflurane) or TIVA group (anaesthesia with propofol). Vocal cord injuries were examined by stroboscopy before and 24 and 72 h after surgery; hoarseness was assessed up to 72 h.

Enrollment: 65 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• orotracheal intubation
• surgery of the ear
• written consent
• ASA I-III

Exclusion criteria

• preexisting pathologies of the vocal cords
• obesity
• difficult airway

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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65 participants in 2 patient groups

Sevoflurane

Active Comparator group

Description:

Anesthesia was maintained with sevoflurane during surgery.

Treatment:

Drug: Sevoflurane

Anesthesia with propofol

Active Comparator group

Description:

Anesthesia was maintained with propofol during surgery.

Treatment:

Drug: propofol