Laser Iridotomy Versus Surgical Iridectomy in Early Angle Closure

Sun Yat-sen University

Status: Unknown

Conditions: Peripheral Anterior Synechiae Increasing; Intraocular Pressure Changes

Treatments: Procedure: Surgical Iridectomy; Procedure: Laser Iridotomy

Study type: Interventional

Funder types: Other

Identifiers

NCT01468103

19831105gaoxinbo

Details and patient eligibility

About

This is a randomized controlled clinical trial to compare laser peripheral iridotomy(LPI) and surgical peripheral iridectomy. Subjects of primary angle closure suspect, primary angle closure will be randomized to undergo LPI or SPI. Subjects are proposed to be followed up for 3 years.

Full description

The following will be studied:

1. To evaluate the safety of these two techniques for the treatment of angle closure.
2. To compare the anterior chamber reaction and IOP changes post surgery.
3. TO establish the UBM/ASOCT chamber angle parameters changes pre and post surgery.
4. To assess the development of PAS.

Enrollment: 120 estimated patients

Sex: All

Ages: 50 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. more than 50 years old
2. Diagnosis of either: Primary angle closure suspects, Primary angle closure in need of laser iridotomy or surgical iridectomy
3. Able to give Informed concent

Exclusion criteria

1. Ophthalmic diseases other than glaucoma and cataract
2. pseudophakic or aphakic patients
3. inability to attend regular follow-up assessment or to give informed written consent
4. Secondary causes of angle closure e.g. subluxed lens, uveitis, trauma and neovascular glaucoma
5. Participating in another study
6. monocular patients

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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120 participants in 2 patient groups

PACS

Experimental group

Description:

primary angle closure suspects

Treatment:

Procedure: Laser Iridotomy

Procedure: Surgical Iridectomy

PAC

Experimental group

Description:

primary angle closure

Treatment:

Procedure: Laser Iridotomy

Procedure: Surgical Iridectomy