Laser Outcomes Associated With (Holmium Laser Enucleation of the Prostate) HoLEP Procedures

Northwestern University

Status: Enrolling

Conditions: Prostate Obstruction; Urologic Diseases

Treatments: Procedure: HoLEP

Study type: Interventional

Funder types: Other

Identifiers

NCT06531473

STU00220458

Details and patient eligibility

About

The primary aim is to assess the impact of laser setting frequency and wattage during holmium laser enucleation of the prostate. There is currently no gold-standard laser settings for HoLEP procedures. In the investigator's current high-volume practice, the following settings for enucleation are: 2j 50hz. These settings are conventional settings, but there is no literature to prove optimal laser settings. The investigators hypothesizes that utilization of higher laser settings may be associated with a clinically significant (defined as > 10%) decrease in procedural time without any detrimental postoperative outcomes, and a utilization of lower laser settings may be associated with a clinically significant (defined as >10%) reduction in postoperative irritative voiding symptoms without any detrimental postoperative outcomes.

Enrollment: 300 estimated patients

Sex: Male

Ages: 18 to 89 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Males 18-89 who are undergoing HoLEP for the treatment of bothersome lower urinary tract symptoms, that are typically caused by enlarged prostates

Exclusion criteria

• Prostates measurements over 200g
• Patients who lack decisional capacity
• Patients who are non-english speakers

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Single Blind

---

300 participants in 3 patient groups

2J 40hz Laser Energy

Experimental group

Description:

Patients will under go their Holmium Laser Enucleation procedure with the laser setting: 2J 40hz

Treatment:

Procedure: HoLEP

2J 50hz Laser Energy

Experimental group

Description:

Patients will under go their Holmium Laser Enucleation procedure with the laser setting: 2J 50hz

Treatment:

Procedure: HoLEP

2J 60hz Laser Energy

Experimental group

Description:

Patients will under go their Holmium Laser Enucleation procedure with the laser setting: 2J 60hz

Treatment:

Procedure: HoLEP