Laser Therapy Treatment of Peri-implantitis.

University of Michigan

Status and phase

Withdrawn

Phase 3

Conditions

Peri-implantitis

Treatments

Procedure: Laser

Procedure: Mechanical debridement

Study type

Interventional

Funder types

Other

Identifiers

NCT01972399

HUM00077816

Details and patient eligibility

About

The primary objective of this study is to compare the clinical outcomes of using Er: YAG laser along with bone graft and barrier membrane to conventional mechanical debridement also with bone graft and barrier membrane in the treatment of peri-implantitis infections.

Sex

All

Ages

18 to 85 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Patients, aged 18 - 85 years
Physical status according to the American Society of Anesthesiologists (ASA) I or II, which includes patients who are systemically healthy or suffer under mild to moderate, but well controlled systemic diseases.
Patients having a minimum of 1 dental implant with peri-implantitis.
The dental implant with peri-implantitis has ≥ 3 threads exposed or pocket probing depth (PPD) ≥ 5mm, with bleeding on probing (BOP) and/or suppuration (pus).
The implants are in function for at least 6 months
No uncontrolled systemic disease or condition known to alter bone metabolism, like Osteoporosis, Osteopenia, Hyperparathyroidism, Paget's disease.
Only rough surface implant will be included in this study

Exclusion criteria

Long-term use of antibiotics > 2 weeks in the past two months
No peri-implantitis treatment in the last 2 months
Patients taking medications known to modify bone metabolism (such as bisphosphonates, corticosteroids, Hormone replacement therapy for menopausal women, Parathyroid hormone, Denosumab, strontium ranelate).
Pregnant females or those planning to become pregnant.
Patients with a history of medically diagnosed oral cancer, bisphosphonate usage, Sepsis or those having adverse outcomes to oral procedures in the past, will be excluded
Mobility of dental implants
History of alcoholism or drug abuse
Current smokers or quit smoking less than 6 months
Diseases of the immune system or any medical condition that may influence the outcome (uncontrolled diabetes (HbA1c >7)
Patients with allergies known to affect one or more of the treatment provided in this study
Polish surface implants
Implants with trabecular surface