Laser Treatment of Basal Cell Carcinoma Under Imaging Guidance

Henry Ford Health

Status

Completed

Conditions

Carcinoma, Basal Cell

Treatments

Device: Treatment of basal cell carcinoma with Nd:YAG laser under imaging guidance of optical coherence tomography (OCT)

Study type

Interventional

Funder types

Other

Identifiers

NCT05138328

14488

Details and patient eligibility

About

This pilot study will examine the treatment of basal cell carcinoma (BCC) with laser technology under the guidance of imaging modalities to assist with surgical excision, including optical coherence tomography imaging (OCT) and reflectance confocal microscopy (RCM). The laser modality that we plan to use is the long-pulse Nd:YAG 1064nm laser, which is a nonablative laser already shown to effectively treat BCC. The addition of OCT and RCM has the opportunity to enhance outcomes by better targeting the treatment and permitting more precise monitoring of clearance. OCT is being used to enhance the effectiveness of Mohs Micrographic Surgery of these cancers by elucidating more definitive tumor margins. RCM has been shown to detect changes in the composition of cells consistent with BCC.

We propose to use these imaging devices to guide the laser treatment to achieve optimal efficacy with minimized side-effects. Primary outcome measured include complete clearance of the BCC lesion, which will be determined through clinical examination, dermoscopy, imaging (OCT and/or RCM), and saucerization biopsy. Secondary outcome variables include the significance of lesion depth (by OCT and/or RCM), lateral extent (by OCT and/or RCM), BCC type, and anatomical region on rate of clearance and recurrence.

Enrollment

31 patients

Sex

All

Ages

18 to 105 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Age 18 or older
At least one (1) biopsy-proven superficial or nodular BCC, less than or equal to 2.0 cm in largest dimension
Willing to have photographs taken of the treatment area
Ability to understand and carry out subject instructions or be represented by a legally authorized guardian or representative

Exclusion criteria

Pregnancy
Patients with a BCC lesion that requires excision. This would include relatively large lesions (greater than or equal to >2.0 cm diameter), lesions that penetrate deep into the skin beyond the depth of the OCT image capture, high risk lesions as defined by the American Academy of Dermatology as recurrent and sclerosing subtype BCC, or metastases.
Subjects unable to follow-up for the full 12 months
Subjects not willing to have biopsy taken from the treatment area
Subjects with herpes simplex virus infection in treatment areas.