Laser Versus Cryotherapy for the Treatment of Recalcitrant Warts

The 306 Hospital of People's Liberation Army

Status: Not yet enrolling

Conditions: Warts

Treatments: Other: laser treatment; Other: cryotherapy

Study type: Interventional

Funder types: Other

Identifiers

NCT05616078

306PLA-004

Details and patient eligibility

About

To evaluate whether laser was superior to cryotherapy for recalcitrant warts

Full description

Patients with recalcitrant warts were randomized equally to receive laser or cryotherapy every 3 to 4 weeks, for a maximum of 4 sessions.The primary outcomes were the cure rate at 16 weeks; secondary outcomes included time to clearance of warts, patient satisfaction with the treatment and treatment-related adverse effects.

Enrollment: 110 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with HPV2/27/57-induced recalcitrant warts, including periungualor mosaic warts, common or plantar warts with a duration of longer than 1 year, and common or plantar warts previously received no more than two sessions of cryotherapy
• Total number of warts is ≤10 .
• Aged 18 years or older.

Exclusion criteria

• Patients are currently participating in another trial for the treatment of cutaneous warts.
• Patients have taken immunosuppressant drugs (such as oral corticosteroids) during the past three months.
• Patients have impaired healing eg due to diabetes, vitamin A deficiency, hyperthyroidism and hypothyroidism.
• Patients have autoimmune diseases (such as systemic lupus erythematosus, dermatomyositis, scleroderma or other diseases).
• Patients are pregnant or ready for pregnancies or breast-feeding.
• Patients have cold intolerance (such as cold urticaria, cryoglobulinaemia, cold agglutinin syndrome or Raynaud's syndrome).
• Patients have local pain intolerance.
• Patients have local hypoesthesia.
• Patients are unable to tolerate laser or cryotherapy.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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110 participants in 2 patient groups

laser treatment

Experimental group

Description:

LP-Nd:YAG laser treatment

Treatment:

Other: laser treatment

cryotherapy

Active Comparator group

Description:

cryotherapy with liquid nitrogen

Treatment:

Other: cryotherapy