LATE LUTEAL PHASE VS. CONVENTIONAL EARLY FOLLICULAR PHASE START IN IVF

Clinia de fertilización Asistida en el Hospital ABC

Status: Not yet enrolling

Conditions: IVF

Treatments: Other: Ovarian Stimulation Start

Study type: Interventional

Funder types: Other

Identifiers

NCT06551376

NPI010924

Details and patient eligibility

About

To compare cycle outcomes after scheduling with the standard early follicular phase (EFP) versus late luteal phase (LLP) in patients undergoing GnRH antagonist cycles.

Full description

Objective To compare cycle outcomes after scheduling with the standard early follicular phase (EFP) versus late luteal phase (LLP) in patients undergoing GnRH antagonist cycles.

Design Multicentric prospective non-randomized study

Setting Two university-affiliated private assisted reproduction centers.

Patient(s) Regularly cycling women aged ≤40 years with fewer than one previous IVF attempts were enrolled. Previous low responses to controlled ovarian hyperstimulation, ovarian surgery, or polycystic ovary were exclusion criteria.

Intervention(s) Twenty patients started controlled ovarian stimulation (COS) after spontaneous menses; similarly, twenty patients started stimulation on the Friday previous to a spontaneous menses (at the end of late luteal phase), regardless of cycle day.

Main Outcome Measure(s) Primary outcome: number of mature oocytes retrieved. Secondary outcomes: fertilization rate, viable embryo rate per oocyte retrieved, cancellation rate, and clinical pregnancy outcomes from FET cycles.

Enrollment: 40 estimated patients

Sex: Female

Ages: 20 to 42 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Regularly cycling women aged ≤40 years with fewer than one previous IVF attempts were enrolled

Exclusion criteria

• Previous low responses to controlled ovarian hyperstimulation, ovarian surgery, or polycystic ovary were exclusion criteria

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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40 participants in 2 patient groups, including a placebo group

Early Follicular Phase ovarian stimulation

Placebo Comparator group

Description:

Twenty patients started controlled ovarian stimulation (COS) after spontaneous menses

Treatment:

Other: Ovarian Stimulation Start

Late Luteal Phase ovarian stimulation

Active Comparator group

Description:

Twenty patients started stimulation on the Friday previous to a spontaneous menses (at the end of late luteal phase), regardless of cycle day.

Treatment:

Other: Ovarian Stimulation Start