Late Onset Postoperative Nausea and Vomiting

King Khaled Eye Specialist Hospital

Status: Completed

Conditions: Postoperative Nausea and Vomiting

Treatments: Drug: Midazolam, dexamethasone; Drug: Placebo; Drug: Ondansetron, Dexamethasone

Study type: Interventional

Funder types: Other

Identifiers

NCT00918190

RP 0917

Details and patient eligibility

About

The purpose of this trial is to study the effects of different combinations of antiemetics on the incidence of late onset postoperative nausea and vomiting.

Full description

The authors will study the effect of many antiemetics on the occurrence of nausea and vomiting following strabismus surgery in pediatrics.

Enrollment: 75 estimated patients

Sex: All

Ages: 4 to 12 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• children undergoing elective strabismus surgery under general anesthesia

Exclusion criteria

• children experienced retching or vomiting
• children who have taken anti-emetic medications, antihistaminics, steroids, or psychoactive drugs within 24 hours before surgery

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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75 participants in 3 patient groups, including a placebo group

Ondansetron-Dexa group

Active Comparator group

Description:

Use 2 different antiemetics

Treatment:

Drug: Ondansetron, Dexamethasone

Midazolam, Dexa group

Active Comparator group

Description:

use of midazolam and dexamethasone

Treatment:

Drug: Midazolam, dexamethasone

Placebo

Placebo Comparator group

Description:

Saline will be given

Treatment:

Drug: Placebo