Latent TGF-β-binding Proteins Affect the Fibrotic Process in Renal Impairment and Cardiac Dysfunction

National Taiwan University

Status: Enrolling

Conditions: Acute Coronary Syndrome With Renal Dysfunction; Acute Coronary Syndrome

Study type: Observational

Funder types: Other

Identifiers

NCT04998227

202103008RINB

Details and patient eligibility

About

The project is planed to explore the impact of LTBP4 and other matrix protein and potentially related biomarkers on renal outcomes, cardiac outcomes and all-cause mortality in patients with suspected acute coronary syndrome (ACS).

Full description

The investigators will collect the blood samples from patients with suspect ACS. LTBP4 will be the first matrix protein that are going to understand. Upon hospital arrival, blood samples around 8 ml will be collected and the 2nd collection will be two weeks to one month after the event. The third collection will be one year later. In the between, if any ACS event develop, blood samples will be collected as protocols.

Enrollment: 300 estimated patients

Sex: All

Ages: 20 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• acute coronary syndrome patients

Exclusion criteria

• cardiogenic shock, pregnancy, end-stage renal disease

Trial design

300 participants in 1 patient group

suspect acute coronary syndrome

Description:

Subjects with the diagnosis of suspected acute coronary syndrome (ACS), age between 20 to 80. Exclusion criteria: pregnant women, patients with end-stage renal disease (eGFR \<15 mL/min/1.73 m2), cardiogenic shock.