Latent Tuberculosis in Second Generation Immigrants From High Risk Countries Compare to Low-risk Young Israeli Adults

Sheba Medical Center

Status

Completed

Conditions

Latent Tuberculosis

Treatments

Procedure: Answering the study Questionnaire and blood sampling for Interferon gamma release assay (IGRA)

Study type

Interventional

Funder types

Other

Identifiers

NCT02073669

SHEBA-13-0668-DS-CTIL

Details and patient eligibility

About

The aim of study is to evaluate the prevalence of latent TB in second generation immigrants from countries with high incidence of tuberculosis (above 20 of 100,000) compare to the control native Israelis without a family member who was born in a country with high incidence of tuberculosis. Using study questionnaire IGRA and tuberculin skin test the investigators expect that the second generation immigrants group will have more positive IGRA test than the control native group.

Enrollment

115 patients

Sex

All

Ages

18 to 25 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Age 18-25
Men and women
Second generation immigrants from countries with high incidence of tuberculosis (above 20 of 100,000).
Native Israelis without a family member who was born in a country with high incidence of tuberculosis.

Exclusion criteria

Prior contact with a tuberculosis patient
Working (more than a month) in high risk setting such as health care workers, working with immigrants from countries with high incidence of tuberculosis.
HIV infection and any immunodeficiency condition.
Recent live-virus vaccination
Acute infectious disease
Prior serious reaction to tuberculin skin test
Pregnancy