Latent Tuberculosis Infection in Renal Transplant Recipients

Asan Medical Center

Status: Completed

Conditions: Renal Transplant

Study type: Observational

Funder types: Other

Identifiers

NCT00682045

AMC-20080169

Details and patient eligibility

About

The aim of this study is to estimate the usefulness of a T cell-based assay (i.e. T-SPOT.TB assay) for diagnosis of latent tuberculosis infection (LTBI) in renal transplant recipients. For this purpose, the investigators enrolled renal transplant recipients and observed the developement of tuberculosis within 1 to 2 years after the transplantation.

Full description

We evaluate the usefulness of a newly-developed T cell-based assay prior to undergoing immunosuppression in renal transplant recipients. Among all renal transplant recipients, patients with negative tuberculin skin test and no other indications for latent tuberculosis infection will be enrolled in this study. We will exam T-SPOT.TB test in these patients, and observe the developement of tuberculosis within 1 to 2 years after the transplantation. The results of T-SPOT.TB will be blinded to the investigators.

Enrollment: 240 estimated patients

Sex: All

Ages: 16+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 16 or more
• Negative tuberculin skin test (induration less than 10 mm)

Exclusion criteria

• Recent contact of patients with active pulmonary tuberculosis
• Suspected active tuberculosis

Trial design

240 participants in 1 patient group

T-SPOT.TB positive

Description:

T-SPOT.TB positive patients