Laxation and Satiety Response of Novel Dietary Fibers

University of Minnesota (UMN)

Status

Completed

Conditions

Healthy

Treatments

Dietary Supplement: Glucose polymer fiber

Dietary Supplement: Fiber made from corn starch

Dietary Supplement: placebo

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT01102881

0902M60241

Details and patient eligibility

About

Dietary fibers have previously been shown to affect laxation and satiety. Due to differences in structure and physical properties of dietary fibers, these effects may not be consistent across all fibers. Therefore as new dietary fibers are created or discovered the laxative and satiating effects should be investigated in order to verify these effects.

Full description

This study was designed to test the laxative effects of two fibers a resistant starch made from corn and a glucose polymer fiber. The secondary aim of this study was to examine the satieting effects of these fibers. This trial was double-blind and placebo controlled. On the first day of the study subjects consumed the breakfast cereal and milk and were instructed to complete visual analog scales periodically to test acute satiety. Subjects also completed diet records and tolerance questionnaires on days 1,2, and 10. Additionally subjects completed another satiety survey on day 10 to test chronic satiety. Whole gut transit time, fecal weight, and fecal chemistry was tested by swallowing radioopaque pellets on day 6 and collecting every fecal sample for the 5 days thereafter.

Enrollment

36 patients

Sex

All

Ages

18 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

healthy men and women
age 18-65
non-smoking
not taking medication
non-dieting (weight stable in prior 3 months)
BMI 18-30
English literacy

Exclusion criteria

do not regularly consume breakfast
food allergies to ingredients found in study product
dislike of cereal or muffins
BMI <18 or >30
diagnosed with cardiovascular, renal, or hepatic disease
diabetes mellitus (fasting blood glucose > 126 mg/ml)
cancer in previous 5 years (except basal cell carcinoma of the skin)
any gastrointestinal disease or condition
recent bacterial infection (< 3 months)
recent or concurrent participation in an intervention research study
history of drug or alcohol abuse in prior 6 months
use of lipid-lowering, anti-hypertensive, or anti-inflammatory steroid medications vegetarians people who eat more than approximately 15 grams of dietary fiber per day women who are pregnant or lactating women with irregular menstrual cycles consumption of prebiotics or probiotics