Lean Seafood Intake and Postprandial Metabolism (LeSIP)

National Institute of Nutrition and Seafood Research, Norway

Status: Completed

Conditions: Metabolic Diseases; Nutrition Disorders; Hyperlipidemias; Glucose Metabolism Disorders; Nutritional and Metabolic Diseases

Treatments: Dietary Supplement: Lean seafood; Dietary Supplement: Meat, egg, milk

Study type: Interventional

Funder types: Other

Identifiers

NCT01708681

2012/1084/REK vest (Other Grant/Funding Number)

NIFES-001

Details and patient eligibility

About

Despite numerous studies of meal components in humans, little is still known about how different meals influence on metabolism. The purpose of this study is to a gain knowledge of how a balanced test meal with either lean seafood (example:cod) or meat as the main protein source will:

1. affect the postprandial metabolism acutely (test-meal at beginning of the study)
2. affect the postprandial metabolism after 4 weeks controlled intervention (test meal at end of intervention period)
3. affect gut microbiota composition

Enrollment: 27 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 18-65 years of age
• Caucasian

Exclusion criteria

• Smoking
• Diabetes
• Hysterectomy
• Abnormal bleeding last 6 months
• Use of medication that affects lipid and glucose metabolism
• Large (>10%) alteration in body-weight the last 6 months
• Chronic, metabolic or acute disease or major surgery within last 3 months
• Dietary incompatibility with calcium supplementation and/ or seafood consumption (allergy, intolerance, dislike)

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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27 participants in 2 patient groups

Lean seafood

Experimental group

Description:

Cross-over design, half of the subject will receive lean seafood in study period I and the other half in study period II

Treatment:

Dietary Supplement: Meat, egg, milk

Dietary Supplement: Lean seafood

Meat, egg, milk

Active Comparator group

Description:

Cross-over design, half of the subject will receive meat, egg, milk in study period I and the other half in study period II

Treatment:

Dietary Supplement: Meat, egg, milk

Dietary Supplement: Lean seafood