Lectine Pathway in Unstable Carotid Plaque

Institute of Hospitalization and Scientific Care (IRCCS)

Status: Withdrawn

Conditions: Mannose-Binding Lectin Complement Pathway; Carotid Artery Plaque

Treatments: Procedure: Carotid endoarterectomy

Study type: Observational

Funder types: Other

Identifiers

NCT03822195

2124

Details and patient eligibility

About

The study is aimed to investigate the possible role of lectin pathway - an alternative pathway of complement activation - in affecting stability of carotid atherosclerotic plaques and the possible correlations with clinical neurologic features.

Full description

In addition to the known hemodynamic criteria, instable carotid plaques can be responsible for brain ischemia, therefore is paramount to identify preoperatively possible markers of plaque instability. The study is aimed to investigate the possible role of lectin pathway - an alternative pathway of complement activation - in affecting stability of carotid atherosclerotic plaques and the possible correlations with clinical neurologic features. Study population will include 40 patients with internal carotid artery stenosis >=70% (assessed by echocolordoppler), symptomatic or asymptomatic, surgically treated by endoarterectomy. Removed plaques will be evaluated by histologic exam and immunofluorescence for ficolins 1-2-3 and Mannose Binding Lectin (MBL). Plasma samples will be used for ELISA test of lectin pathway complement activation.

Sex: All

Ages: 40 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients undergone elective or urgent carotid endoarterectomy (CEA) for internal carotid stenosis >70% (assessed by velocimetric criteria) with or without neurologic symptoms

Exclusion criteria

• recent (<20 days) major/minor stroke with positive CT scan
• absolute contraindications to surgery (cardiac, respiratory, anesthesiologic risk)

Trial design

0 participants in 2 patient groups

asymptomatic

Description:

asymptomatic patients undergoing carotid endoarterectomy for stenosis \>70% (velocimetric criteria at echodoppler)

Treatment:

Procedure: Carotid endoarterectomy

symptomatic

Description:

symptomatic (TIA, crescendo TIA, minor stroke) patients undergoing carotid endoarterectomy, independently from stenosis evaluated by echodoppler

Treatment:

Procedure: Carotid endoarterectomy