LEft Atrial Pacing in Diastolic Heart Failure (LEAD)

University Hospital Center (CHU) Dijon Bourgogne

Status: Completed

Conditions: Heart Failure With Preserved Ejection Fraction; Left Atrio-ventricular Asynchrony; Atrial Dyssynchrony Syndrome

Treatments: Procedure: pace make active/inactive cross over

Study type: Interventional

Funder types: Other

Identifiers

NCT01618981

LAURENT PHRC N 2011

Details and patient eligibility

About

The purpose of this study is to assess left atrial pacing therapy in patients with atrial dyssynchrony syndrome and heart failure with preserved ejection fraction.

Sex: All

Ages: 65+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Age ≥ 65
• Sinus rhythm, PR < 220ms, QRS < 110ms
• Heart failure (NYHA class III-IV or II with hospitalization for heart failure)
• Ejection Fraction > 50%, restrictive mitral inflow, Lateral E/e' > 12 or septal E/e' > 15, Left atrial index volume > 34 ml/m²
• Atrial dyssynchrony syndrome: (TTE) inter-atrial time delay ≥ 70ms (difference between tricuspid and mitral P-A intervals or between mitral and tricupsid P-A' intervals with DTI)
• Left atrio-ventricular asynchrony: Time Difference between tricupsid and mitral A wave duration ≥ 35ms.

Trial design

0 participants in 2 patient groups

first active

Experimental group

Treatment:

Procedure: pace make active/inactive cross over

first inactive

Experimental group

Treatment:

Procedure: pace make active/inactive cross over