Left Atrial Remodelling in Hypertension: Effects of Ramipril or Irbesartan

Università degli Studi dell'Insubria

Status and phase: Unknown; Phase 4

Conditions: Diastolic Function; Antihypertensive Drugs; Left Atrial Volume; Renin Angiotensin System; Hypertensive Heart Disease

Treatments: Drug: irbesartan; Drug: ramipril

Study type: Interventional

Funder types: Other

Identifiers

NCT00517322

1112

Details and patient eligibility

About

Aim of the study is to compare in hypertensive patients the effect of one year therapy with ACE-inhibitor (RAMIPRIL) or angiotensin II receptor blocker (IRBESARTAN) on left atrial remodelling and diastolic function.

Enrollment: 80 estimated patients

Sex: All

Ages: 40 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:·

• mild to moderate essential hypertension
• no antihypertensive treatment
• good quality echocardiogram

Exclusion Criteria:

• cardiovascular diseases (AMI, stroke o TIA)
• heart failure, valvular heart disease
• diabetes
• secondary hypertension
• atrial fibrillation
• hepatic and renal severe failure
• pregnancy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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80 participants in 2 patient groups

1

Experimental group

Description:

treatment with ramipril

Treatment:

Drug: ramipril

2

Experimental group

Description:

treatment with irbesartan

Treatment:

Drug: irbesartan