Left Bundle Branch Pacing Versus Right Ventricular Pacing in Patients With Atrioventricular Block

Sichuan University

Status: Enrolling

Conditions: AVB - Atrioventricular Block

Treatments: Procedure: Right ventricular pacing (RVP); Procedure: left bundle branch pacing (LBBP)

Study type: Observational

Funder types: Other

Identifiers

NCT05722379

WestChinaH-LBBP-001

Details and patient eligibility

About

Although emerging evidence demonstrated that left bundle branch pacing (LBBP) is a promising alternative for patients with either a bradycardia or a heart failure pacing indication. However, a direct comparison of the safety, efficacy and LV systolic synchrony between LBBP and RVP regimens was rare. In this study, the investigators aim to conduct a comparison of the safety and effectiveness performance between these two pacing methods for patients with atrioventricular block (AVB). The investigators focused on AVB patients undergoing permanent pacemaker implantations from the 1st of January 2018 to the 18th of November 2021 at West China Hospital.

Full description

Right ventricular pacing (RVP) is the standard treatment for patients with continuous ventricular pacing needs. However, clinical studies have shown that RVP can cause electrical and mechanical dyssynchrony of the left ventricle and increase the risks of cardiac insufficiency, atrial fibrillation (AF) and death. Although emerging evidence demonstrated that left bundle branch pacing (LBBP) is a promising alternative for patients with either a bradycardia or a heart failure pacing indication. However, a direct comparison of the safety, efficacy and LV systolic synchrony between LBBP and RVP regimens was rare. In this study, the investigators aim to conduct a comparison of the safety and effectiveness performance between these two pacing methods for patients with atrioventricular block (AVB). The investigators focused on AVB patients undergoing permanent pacemaker implantations from the 1st of January 2018 to the 18th of November 2021 at West China Hospital.

Enrollment: 1,000 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• included consecutively high-grade AVB patients undergoing permanent pacemaker implantations from the 1 s t of January 2018 to the 18 thof November 2021 at West China Hospital

Exclusion criteria

• patients with pacemaker replacements were excluded.

Trial design

1,000 participants in 1 patient group

high-grade AVB patients undergoing permanent pacemaker implantations

Treatment:

Procedure: Right ventricular pacing (RVP)

Procedure: left bundle branch pacing (LBBP)