Left Ventricular Diastolic Function During Anesthesia Induction

Universitätsklinikum Hamburg-Eppendorf

Status: Completed

Conditions: Left Ventricular Diastolic Dysfunction

Treatments: Drug: Propofol; Drug: Sevoflurane

Study type: Observational

Funder types: Other

Identifiers

NCT03522194

PV 5436

Details and patient eligibility

About

Diastolic dysfunction is an important cause of hemodynamic instability in the perioperative field.Therefore this study aims to investigate the influence of existing diastolic dysfunction or deterioration of diastolic function on hemodynamic stability during induction of anesthesia and postoperative complications. The impact of different anesthetics on diastolic function is investigated.

Full description

In this prospective observational study two cohorts of patients with different anesthesia regimes are investigated. Anesthesia is maintained with sevoflurane or propofol. Before induction of anesthesia a transthoracic echocardiography is performed to examine systolic and diastolic function. Immediately after induction, during maintenance and after completion of anesthesia any changes of diastolic function are examined with transthoracic echocardiography. All anesthetic medications, fluids, vasoactive medications and catecholamines are registered.

Enrollment: 200 patients

Sex: All

Ages: 60+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients older than 60 years scheduled for general anesthesia

Exclusion criteria

• Mitral regurgitation or stenosis > I°
• Sp. mitral valve repair or replacement
• Pericardial effusion
• Atrial fibrillation/flutter
• Patients with pacemaker
• BMI > 35 kg/m2

Trial design

200 participants in 2 patient groups

Sevoflurane

Description:

Anesthesia maintenance

Treatment:

Drug: Sevoflurane

Propofol

Description:

Anesthesia maintenance

Treatment:

Drug: Propofol