Left Ventricular Diastolic Function During Anesthesia Induction

U

Universitätsklinikum Hamburg-Eppendorf

Status

Completed

Conditions

Left Ventricular Diastolic Dysfunction

Treatments

Drug: Sevoflurane
Drug: Propofol

Study type

Observational

Funder types

Other

Identifiers

NCT03522194
PV 5436

Details and patient eligibility

About

Diastolic dysfunction is an important cause of hemodynamic instability in the perioperative field.Therefore this study aims to investigate the influence of existing diastolic dysfunction or deterioration of diastolic function on hemodynamic stability during induction of anesthesia and postoperative complications. The impact of different anesthetics on diastolic function is investigated.

Full description

In this prospective observational study two cohorts of patients with different anesthesia regimes are investigated. Anesthesia is maintained with sevoflurane or propofol. Before induction of anesthesia a transthoracic echocardiography is performed to examine systolic and diastolic function. Immediately after induction, during maintenance and after completion of anesthesia any changes of diastolic function are examined with transthoracic echocardiography. All anesthetic medications, fluids, vasoactive medications and catecholamines are registered.

Enrollment

200 patients

Sex

All

Ages

60+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Patients older than 60 years scheduled for general anesthesia

Exclusion criteria

  • Mitral regurgitation or stenosis > I°
  • Sp. mitral valve repair or replacement
  • Pericardial effusion
  • Atrial fibrillation/flutter
  • Patients with pacemaker
  • BMI > 35 kg/m2

Trial design

200 participants in 2 patient groups

Sevoflurane
Description:
Anesthesia maintenance
Treatment:
Drug: Sevoflurane
Propofol
Description:
Anesthesia maintenance
Treatment:
Drug: Propofol

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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