Left Ventricular Function After Primary Percutaneous Coronary Intervention: Role of Speckle Echocardiography

Assiut University

Status: Unknown

Conditions: Echocardiography 2D; Myocardial Infarction; Left Ventricular Dysfunction

Treatments: Diagnostic Test: Speckle tracking echocardiography

Study type: Observational

Funder types: Other

Identifiers

NCT04103008

AssiutU2019

Details and patient eligibility

About

Recovery of the left ventricular function is variable from one patient to another, thus assessment of cardiac function by measuring left ventricular ejection fraction using echocardiography is the most common in the daily clinical practice. However, this technique has limitation related with its intra- and interobserver variability. A recent technique, 2D speckle tracking for assessing global longitudinal strain, has been introduced to reduce the variability and potentially has a higher accuracy. Speckle tracking is a method which uses two dimensions recording for measuring quantity of movement of myocardium in several segments.

Speckle-tracking echocardiography is a current noninvasive ultrasound imaging technique that allows for an objective and quantitative evaluation of global and regional myocardial function independently from the angle of insonation and from cardiac translational movements,

Full description

Authors using 2D speckle tracking found that subclinical LV systolic dysfunction is common in patients with isolated severe mitral stenosis (MS) and is determined primarily by the hemodynamic variables of MS severity and reduced LV filling. BMV results in rapid recovery of LV systolic function in these patients through improvement in LV diastolic loading. These findings suggest that LV contractile properties in MS are modulated predominantly by LV diastolic filling rather than myocardial structural abnormality.

Enrollment: 100 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with acute myocardial infarction eligible for PCI seen on admission and after 40 days

Exclusion criteria

• cardiomyopathy
• cancer
• on cytostatic treatment.

Trial design

100 participants in 2 patient groups

Group A

Description:

single coronary artery lesion

Treatment:

Diagnostic Test: Speckle tracking echocardiography

Group B

Description:

multiple coronary artery lesions

Treatment:

Diagnostic Test: Speckle tracking echocardiography