Left Ventricular Lead Position in Cardiac Resynchronization Therapy

RWTH Aachen University

Status: Completed

Conditions: Heart Failure

Treatments: Procedure: Echocardiography (myocardial deformation imaging); Procedure: Implantation of a cardiac resynchronization therapy device

Study type: Observational

Funder types: Other

Identifiers

NCT00748735

MB-2008-CRT

Details and patient eligibility

About

Left ventricular (LV) lead position has crucial impact on cardiac resynchronization therapy (CRT) success. This study will compare fluoroscopy and myocardial deformation imaging for optimal definition of LV lead position.

Full description

In a 16 segment model circumferential strain will be used to determine the segment with latest peak systolic circumferential strain prior to CRT, considered as the optimal LV lead target. LV lead will be defined by (1) fluoroscopy, (2) the maximal temporal difference of peak circumferential strain before-to-on CRT and (3) the earliest peak systolic circumferential strain during LV pacing. For all 3 modalities optimal LV lead position is defined as concordance or immediate neighbouring of the segment with defined LV lead position to the determined optimal target segment. At follow-up echocardiography will be performed to determine improvement in LV function and remodeling.

Enrollment: 55 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• See above
• Males and females
• Ages 18 to 80 years

Exclusion criteria

• Patients who already have had a pacemaker device
• Patients with poor echocardiographic window
• Patients who are not able to understand the study and to give informed written consent

Trial design

55 participants in 1 patient group

A1

Description:

heart failure patients undergoing CRT implantation

Treatment:

Procedure: Implantation of a cardiac resynchronization therapy device

Procedure: Echocardiography (myocardial deformation imaging)