Left Ventricular Mass Index Predicts Clinical Outcomes in Patients with Obstructive Hypertrophic Cardiomyopathy Undergoing Septal Myectomy (LVMI and oHCM)

Changrong Nie

Status: Completed

Conditions: Obstructive Hypertrophic Cardiomyopathy (oHCM)

Treatments: Other: Patients had a higher left ventricular mass index or not （the exact value is determined by the cut-off value for the clinical outcomes)

Study type: Observational

Funder types: Other

Identifiers

NCT06609382

2020-1315

2022-GSP-GG-29 (Other Grant/Funding Number)

Details and patient eligibility

About

In this study, we aimed to analyze the association between left ventricular mass index and clinical outcomes to provide the potential indicator for worse survival.

Full description

This retrospective study aimed to determine the prognostic value of left ventricular mass index in predicting clinical outcomes, including all-cause death, new-onset or recurrent atrial fibrillation, and a composite endpoint of all-cause death, heart failure,permanent pacemaker implantation, new-onset or recurrent atrial fibrillation, and stroke.

Enrollment: 490 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:(1) Difficulty in relieving symptoms with medication or recurrent syncope. (2) Left ventricular outflow tract (LVOT) pressure gradient ≥ 50 mmHg at rest or with provocation and the maximum thickness of the septum is ≧ 15 mm.

Exclusion Criteria:

• (1) Combined right ventricular outflow tract obstruction requiring right ventricular outflow tract dissection. (2) Combined mitral or aortic valve organic lesions requiring valve replacement surgery. (3) Apical ventricular aneurysm formation requiring ventriculotomy. (4) Previous septal reduction therapy, including alcohol ablation or septal myectomy. (5) patients did not undergo cardiac magnetic resonance examination.

Trial design

490 participants in 1 patient group

Obstructive hypertrophic cardiomyopathy who underwent septal myectomy

Description:

Patients who had at least one cardiac magnetic resonance examination before surgery.

Treatment:

Other: Patients had a higher left ventricular mass index or not （the exact value is determined by the cut-off value for the clinical outcomes)