Leptin and Ghrelin in ICU

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Status and phase: Completed; Phase 4

Conditions: Critically Ill

Treatments: Other: enteral feeding by nasogastric tube.

Study type: Interventional

Funder types: Other

Identifiers

NCT02282501

Odu-4

Details and patient eligibility

About

Enteral alimentation is the preferred modality of support in critical patients who have acceptable digestive function and are unable to eat orally, but the advantages of continuous versus intermittent administration are surrounded by controversy.

This prospective, randomised study was designed to compare two enteral feeding methods with respect to changes in levels of leptin and ghrelin in ICU.

Enrollment: 40 patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• who were unable to ingest an oral diet
• given decision on enteral feeding

Exclusion criteria

• Carcinomatosis
• irreversible coma
• death or discharge before 14 days of observation
• contraindication to enteral feeding
• intolerance to the prescribed nutrients or infusion regimen
• burn
• multiple trauma
• morbid obesity
• end stage liver or renal or lung disease
• severe sepsis or septic shock
• patients with percutaneous endoscopic gastrostomy
• immunosuppressive drug use
• severe hemodynamic instability
• massive blood transfusion

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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40 participants in 2 patient groups

intermittent feeding

Active Comparator group

Description:

Bolus infusion - The total daily feeding period was also 4-6 times a day.

Treatment:

Other: enteral feeding by nasogastric tube.

continuous feeding

Active Comparator group

Description:

Continuous infusion - The daily desired amount was offered continuously for 20 hours a day.

Treatment:

Other: enteral feeding by nasogastric tube.