Leptin and Visfatin in Diabetic Patients With Periodontitis Before and After Periodontal Therapy

Cairo University (CU)

Status: Completed

Conditions: Type 2 Diabetes Mellitus; Chronic Periodontitis

Treatments: Procedure: non-surgical periodontal therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT02174146

leptin_visfatin_diabetes

Details and patient eligibility

About

1. Are adipokines involved in pathogenesis of periodontal disease in diabetic patients?
2. Does their level change after periodontal therapy?

Full description

Patients with chronic periodontitis only and patients with chronic periodontitis and diabetes were evaluated for levels of leptin and visfatin in the gingival tissues before and after non-surgical periodontal therapy.

Enrollment: 50 patients

Sex: All

Ages: 35 to 54 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• diabetic patients having diabetes mellitus ≥5 years prior to the study.
• chronic periodontitis with clinical attachment loss > 5 mm.
• otherwise systemically healthy subjects.

Exclusion criteria

• any known systemic diseases other than diabetes.
• pregnancy or lactation.
• smokers.
• receiving periodontal treatment in the last 6 months.
• taking any drugs or medications other than anti-diabetic drugs.

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: Single Blind

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50 participants in 1 patient group

non-surgical therapy

Other group

Description:

non-surgical periodontal therapy with ultrasonic scalers and periodontal curettes

Treatment:

Procedure: non-surgical periodontal therapy