Leptin Biology in Adipose Tissue

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Mayo Clinic

Status

Completed

Conditions

Obesity

Treatments

Other: obesity

Study type

Interventional

Funder types

Other

Identifiers

NCT01800864
11-003834

Details and patient eligibility

About

Leptin is a fat hormone which acts in maintaining energy balance. However, leptin levels are high in obese subjects indicating resistance to the actions of leptin. High leptin levels have been associated with increased cardiovascular and metabolic risks, but it is not clear if increased leptin or leptin resistance contributes to the increased cardiovascular risk. Further, even though leptin receptors are present in fat tissue, leptin's role in fat tissue functions are not completely investigated in humans. Based on preliminary data the investigators hypothesize that resistance to leptin action in obese adipose tissue is responsible for altering the expression of adipose tissue proteins which contribute to the development of cardiovascular and metabolic dysfunction. To test this hypothesis the investigators propose a novel study directed at investigating the leptin dependent changes in adipose tissue protein expression using adipose tissue obtained from lean and obese human subjects

Enrollment

5 patients

Sex

All

Ages

18 to 75 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  1. Age 18-75 years
  2. BMI BMI ≤25 (lean) or >30 kg/m2 (obese)
  3. Going to undergo a surgical procedure where omental and subcutaneous adipose tissue may be biopsied.

Exclusion criteria

Inability to provide written informed consent.

Trial design

Primary purpose

Basic Science

Allocation

Randomized

Interventional model

Single Group Assignment

Masking

None (Open label)

5 participants in 2 patient groups

Normal
Other group
Description:
Normal weight subjects
Treatment:
Other: obesity
Over weight /obese subjects
Other group
Description:
Overweight and obese subjects
Treatment:
Other: obesity

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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