Leptin Receptors in the Bariatric Surgical Population Within the University of Pittsburgh Medical System: A Cohort Study

University of Pittsburgh

Status: Completed

Conditions: Obesity

Study type: Observational

Funder types: Other

Identifiers

NCT02093416

PRO13010529

Details and patient eligibility

About

Prospective cohort study evaluating the role of leptin receptors in the bariatric surgical population compared with non obese controls. Additionally serum levels of leptin, ghrelin, motilin and PYY will be compared amongst the different BMI classes and a quality of life questionnaire completed by all participants.

The hypothesis is that obese individuals have lower leptin receptors in enterocytes which is partially responsible for the higher serum leptin levels without appropriate control of satiety.

Enrollment: 50 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Endoscopic Intervention

Exclusion criteria

• 18 years of age or older
• No acute GI bleeding

Trial design

50 participants in 4 patient groups

Group 1: Control Group

Description:

BMI \<30 There are 20 controls in this group

Group 2

Description:

BMI 30-35 There were 12 controls in this class

Group 3

Description:

BMI 35-40 There were 9 controls in this clas

Group 4

Description:

BMI \>40 There were 9 controls in this class