Leptin Signaling in Lean and Obese Humans (Leptin signali)

VA Office of Research and Development

Status: Withdrawn

Conditions: Obesity

Study type: Observational

Funder types: Other U.S. Federal agency

Identifiers

NCT01297426

ENDA-013-10F

Details and patient eligibility

About

Obesity does not respond to high circulating levels of the hormone leptin. This study is aiming at finding out why this happens and open new avenues for treatment of obesity.

Full description

Ex vivo and in vitro identification and study of leptin signaling pathways in commercially available cell lines serum/ plasma samples and discarded tissues from humans.

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• men and women
• ages 18 to 65
• BMI ranges between 20 and 45 kg/m2

Exclusion criteria

• subjects requiring special diets
• history of illness other than obesity of diabetes
• taking medications known to influence glucose metabolism
• subjects with history of anaphylactic reaction or hypersensitivity to e. coli derived proteins or anesthetic agents
• women who are breastfeeding, pregnant or wanting to become pregnant
• subjects with bleeding dyscrasia or poor wound healing

Trial design

0 participants in 1 patient group

Group 1

Description:

Lean and obese, diabetic and non diabetics