Leptospirosis Care Bundle Study

Chulalongkorn University

Status: Enrolling

Conditions: Leptospirosis

Treatments: Procedure: Care Bundle

Study type: Interventional

Funder types: Other

Identifiers

NCT05425524

IRB.521/62

Details and patient eligibility

About

So in management of Leptospirosis patients There really is no another approach to treatment. The importance of the problem was acknowledged by the researchers. As a result, this study was performed in order to The Leptospirosis Care Bundle has been used, and has been proved that its use can reduce the risk of acute renal failure.

Enrollment: 300 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age > 18 years
• Suspicious Leptospirosis including body temperature > 38 celcius, Severe myalgia, and exposure to reservoir hospital of flood water.
• Calf muscle tenderness
• Conjunctival suffusion
• Anuria or oliguria and/or proteinuria
• Jaundice
• Hemorrhagic manifestations (pulmonary and intestine)
• Meningeal irritation
• Nausea, vomiting, abdominal pain, diarrhea.
• Admitted in hospital

Exclusion criteria

• other infectious disease
• pregnancy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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300 participants in 2 patient groups

Care Bundle Group

Experimental group

Description:

Treatment step by step we have 5 steps STEP 1: Leptospirosis suspected case STEP 2: Investigations STEP 3: Antibiotics within 1 hour after Hemocultures were taken STEP 4: Intravenous Fluid STEP 5: Stage-Base Management of AKI (KDIGO)

Treatment:

Procedure: Care Bundle

Control Group

No Intervention group