Letrozole and Sequential Clomiphene to Improve the Outcome of Embryo Transfer

Navy General Hospital, Beijing

Status: Unknown

Conditions: Female Infertility Due to Nonimplantation of Ovum

Treatments: Drug: HMG; Drug: clomiphene; Drug: Letrozole

Study type: Interventional

Funder types: Other

Identifiers

NCT02775877

HL2015

Details and patient eligibility

About

The purpose of this study is to study the effects of letrozole and sequential clomiphene in ovulation and pregnancy in PCOS patients.

Full description

To evaluate the efficacy of letrozole and clomiphene in PCOS patients is important,especially in resistent PCOS patients. Although most medications prove the effectiveness of letrozole and clomiphene,the subjects of letrozole and sequential clomiphene in PCOS patients are rarely.The trial may provide further basis for this medication in PCOS patients in ovulation. If the medication demonstrates efficacy, the method would help the patients with PCOS to deal with the problem of infertility.

Enrollment: 100 estimated patients

Sex: Female

Ages: 20 to 38 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Women with PCOS

Exclusion criteria

• •Women more than 38 years or less than 20 years

  • With infectious diseases or endocrine diseases
  • Who refuse to participate in the experiment

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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100 participants in 2 patient groups

letrozole and clomiphene

Experimental group

Description:

Letrozole 5 mg tablet orally from 3-7 day of once a day menstrual cycle and clomiphene100 mg tablet orally once a day from 11-15 day of menstrual cycle.

Treatment:

Drug: Letrozole

Drug: clomiphene

Letrozole and human menopausal gonadotropin (HMG)

Active Comparator group

Description:

Letrozole 5 mg tablet orally from 3-7 day of once a day menstrual cycle and HMG 75u once a day by intramuscular injection from 11-15day of menstrual cycle

Treatment:

Drug: HMG

Drug: Letrozole