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the aim of the study is to compare between the step-up and conventional protocols in ovulation induction in infertile women with PCOS
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The current study was conducted in private outpatient clinic after being approved by the medical ethics committee. The study is a prospective randomized study consisting of 90 Egyptian patients diagnosed as having infertility with pcos .
Sample size determination:
Group sample sizes of 42 and 42 achieve 80% power based on study finding carried out by (Galal et al., 2014) to detect a difference of 0.7 between the null hypothesis that both group means are 2.2 and the alternative hypothesis that the mean of group 2 is 1.5 with known group standard deviations of 1.5 and 0.6 and with a significance level (alpha) of 0.05000 using a two-sided Mann-Whitney test assuming that the actual distribution is uniform.
Sample size was calculated by PASS 11 Computer program for sample size calculation.
Taking into consideration 10% drop out rate, the sample size will be increased to 45 patients in group I and another 45 patients in group II.
Patients were divided into two groups with randomization sheet:
Group (I): includes 45 females taking Letrozole (old regimen).
Group (II): includes 45 females taking Letrozole 5 mg tab in a step-up protocol (new regimen).
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90 participants in 2 patient groups
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Data sourced from clinicaltrials.gov
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