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Leucine and Beta-hydroxy-beta-methylbutyrate (HMB) as Anabolic Nutrients After 36 Hours of Fasting

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University of Aarhus

Status

Completed

Conditions

Nutrition Support
Metabolism
Fasting

Treatments

Dietary Supplement: low leucine content drink
Behavioral: 36 hour fasting
Dietary Supplement: Control/carbohydrate
Dietary Supplement: high leucine content drink
Dietary Supplement: low leucine + HMB drink

Study type

Interventional

Funder types

Other

Identifiers

NCT01840098
1-10-72-63-13

Details and patient eligibility

About

The purpose of this study is to investigate metabolic effects of 3 different nutritional compounds.

Fasting (36 hours) creates a catabolic state that is comparable with the catabolic state seen in acute illness.

This study is a randomized, placebo cross-over study investigating 8 healthy men on 4 separated days (at least 3 weeks between trials).

  • High leucine content drink
  • Low leucine content drink
  • Low leucine content drink + HMB
  • Carbohydrate (isocaloric)

The investigators hypothesize that these nutritional supplements may counteract catabolic processes in different ways and degrees.

Enrollment

8 patients

Sex

Male

Ages

20+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • male gender
  • 20<BMI<30
  • Age > 20 years old
  • Written consent before starting the study

Exclusion criteria

  • Allergy for soya products ore egg
  • Diabetes
  • Epilepsy
  • Infection
  • Immune defects
  • Heart disease
  • Dysregulated hypertension
  • Participating in other trials using radioactive tracers or x-rays the last year.

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

Single Blind

8 participants in 4 patient groups

control
Active Comparator group
Description:
Isocaloric carbohydrate drink
Treatment:
Behavioral: 36 hour fasting
Dietary Supplement: Control/carbohydrate
low leucine content drink
Active Comparator group
Description:
A soy protein drink
Treatment:
Dietary Supplement: low leucine content drink
Behavioral: 36 hour fasting
high content of leucine drink
Active Comparator group
Description:
A whey protein drink
Treatment:
Behavioral: 36 hour fasting
Dietary Supplement: high leucine content drink
low leucine content + HMB drink
Active Comparator group
Description:
Soy protein drink added HMB
Treatment:
Behavioral: 36 hour fasting
Dietary Supplement: low leucine + HMB drink

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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