Leucine and Beta-hydroxy-beta-methylbutyrate (HMB) as Anabolic Nutrients After 36 Hours of Fasting

University of Aarhus

Status: Completed

Conditions: Nutrition Support; Metabolism; Fasting

Treatments: Dietary Supplement: low leucine content drink; Behavioral: 36 hour fasting; Dietary Supplement: Control/carbohydrate; Dietary Supplement: high leucine content drink; Dietary Supplement: low leucine + HMB drink

Study type: Interventional

Funder types: Other

Identifiers

NCT01840098

1-10-72-63-13

Details and patient eligibility

About

The purpose of this study is to investigate metabolic effects of 3 different nutritional compounds.

Fasting (36 hours) creates a catabolic state that is comparable with the catabolic state seen in acute illness.

This study is a randomized, placebo cross-over study investigating 8 healthy men on 4 separated days (at least 3 weeks between trials).

• High leucine content drink
• Low leucine content drink
• Low leucine content drink + HMB
• Carbohydrate (isocaloric)

The investigators hypothesize that these nutritional supplements may counteract catabolic processes in different ways and degrees.

Enrollment: 8 patients

Sex: Male

Ages: 20+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• male gender
• 20<BMI<30
• Age > 20 years old
• Written consent before starting the study

Exclusion criteria

• Allergy for soya products ore egg
• Diabetes
• Epilepsy
• Infection
• Immune defects
• Heart disease
• Dysregulated hypertension
• Participating in other trials using radioactive tracers or x-rays the last year.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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8 participants in 4 patient groups

control

Active Comparator group

Description:

Isocaloric carbohydrate drink

Treatment:

Behavioral: 36 hour fasting

Dietary Supplement: Control/carbohydrate

low leucine content drink

Active Comparator group

Description:

A soy protein drink

Treatment:

Dietary Supplement: low leucine content drink

Behavioral: 36 hour fasting

high content of leucine drink

Active Comparator group

Description:

A whey protein drink

Treatment:

Behavioral: 36 hour fasting

Dietary Supplement: high leucine content drink

low leucine content + HMB drink

Active Comparator group

Description:

Soy protein drink added HMB

Treatment:

Behavioral: 36 hour fasting

Dietary Supplement: low leucine + HMB drink