Leucine Supplementation and Skeletal Muscle Disuse

University of Sao Paulo

Status: Completed

Conditions: Disuse Atrophy

Treatments: Dietary Supplement: Placebo; Dietary Supplement: Leucine

Study type: Interventional

Funder types: Other

Identifiers

NCT01192009

2009/02896-6

Details and patient eligibility

About

Leucine supplementation is widely known for promoting strong influence on skeletal muscle remodeling. This study aims to evaluate the effect of leucine supplementation on disuse-induced skeletal muscle atrophy.

Enrollment: 22 patients

Sex: Male

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Clinical diagnosis of anterior cruciate ligament injury
• Physically active
• Must be able to swallow tablets
• Non-smokers
• Do not use nutritional supplements

Exclusion criteria

• Post-surgical complications

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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22 participants in 2 patient groups, including a placebo group

Immobilization and Leucine

Experimental group

Treatment:

Dietary Supplement: Leucine

Immobilization and Placebo

Placebo Comparator group

Treatment:

Dietary Supplement: Placebo