Leukocyte Dysfunction in Diabetic Patients.

Sashwati Roy

Status: Terminated

Conditions: Diabetes Mellitus, Type 2

Study type: Observational

Funder types: Other

Identifiers

NCT01144520

2009H0270

Details and patient eligibility

About

The purpose of this study is to study impairment of white blood cell function in patients with type II diabetes.

Full description

Leucocytes from poorly controlled diabetes exhibit aberrant chemotaxis, increased susceptibility to bacterial infection, leukotriene production, lysosomal enzyme release, proinflammatory cytokine expression and production of reactive oxygen species. Aberrant glucose concentration in diabetics affects functions of peripheral blood system as well as the immune system leading to impaired host defense. Impaired wound healing is a serious complication associated with diabetes. We hypothesized that impairment in leukocyte function results in dysfunctional inflammatory response in diabetic wounds. The proposed studies focus on characterizing mechanisms that will improve our understanding of the dysfunctional inflammatory response resulting in non-healing chronic wounds in diabetics.

Enrollment: 42 patients

Sex: All

Ages: 40 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Adults ages 40-60 yrs old clinically diagnosed with Type II Diabetes
• Adults ages 40-60 yrs old without Diabetes

Exclusion criteria

• Unable to provide informed consent
• Pregnant Females
• Therapeutically Immuno-compromised

Trial design

42 participants in 4 patient groups

Normoglycemic

Description:

Healthy subjects that do not have diabetes

Type II Diabetes (HbA1c <7 or 7%)

Description:

Subject that have Type II Diabetes with good glucose control with glycated hemoglobin (HbA1c \<7 or 7%)

Type II Diabetes (HbA1c between 7.1-9)

Description:

Subjects with Type II Diabetes with moderate glucose control (HbA1c between 7.1-9)

Type II Diabetes (HbA1c >9%)

Description:

Subjects with Type II Diabetes with poor glucose control (HbA1c \>9%)