Levels of Pigment Epithelium-derived Factor in Patients With Psoriasis.

Sohag University

Status: Unknown

Conditions: Psoriasis

Treatments: Other: serum samples and punch skin biopsies

Study type: Interventional

Funder types: Other

Identifiers

NCT05252741

soh-Med-22-02-04

Details and patient eligibility

About

Psoriasis is an immune-mediated chronic inflammatory skin disease associated with increase interaction of inflammatory mediators like adipokines. Pigment epithelium-derived factor (PEDF) is one of the most abundant adipokines and have anti-angiogenesis effect. There is a study showed that PEDF level is up-regulated in the sera of psoriasis patients.

Enrollment: 52 estimated patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Patients with psoriasis and group of age and sex-matched healthy volunteers will be included as a control group.

Exclusion criteria

• Pregnancy.
• Patients with other inflammatory skin disorders.
• Patients on antioxidants or anti-inflammatory drugs.
• Patients on topical or systemic treatment for psoriasis in the last 4 weeks prior to enrollment in the study.
• Patients on systemic retinoids (Acitretin).
• Obesity: body mass index (BMI ) > 30.
• Malignancies e.g squamous cell carcinoma.
• Viral warts.
• Diabetes.
• Hypertension.

Trial design

Primary purpose: Screening

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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52 participants in 2 patient groups, including a placebo group

Group 1: patients with psoriasis

Active Comparator group

Treatment:

Other: serum samples and punch skin biopsies

Group 2: age-, sex-, BMI-, and weight-matched control subjects.

Placebo Comparator group

Treatment:

Other: serum samples and punch skin biopsies